Although the Cvt pathway is the only known biosynthetic use of autophagy, selectivity represents an important aspect of many autophagic processes. For example, specific organelle degradation has ...

诺贝尔奖委员会于本周一（北京时间）宣布，将 2024 年诺贝尔生理学或医学奖授予维克多·安布罗斯（Victor Ambros）和加里·鲁夫昆（Gary Ruvkun），以表彰他们在微小 RNA（microRNA）及其在“基因沉默”功能方面的发现。图 ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel ...

该研究揭示了幽门螺杆菌关键毒力因子CagA与宿主AUF1蛋白之间的相互作用在幽门螺杆菌致病机制中的重要作用，AUF1表达失调可能增加幽门螺杆菌相关 ...

杂志上在线发表题为《AUF1介导的自噬溶酶体降解抑制有助于CagA稳定性和幽门螺杆菌诱导的炎症》（“AUF1-mediated inhibition of autophagic lysosomal degradation contributes to CagA stability and Helicobacter pylori-induced ...

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...

New research shows astrocytes can remove Alzheimer’s-related amyloid-beta via autophagy, offering a promising new direction ...

A mouse xenograft model of DLBCL tumors was used to characterize the role of TNFAIP3 expression tumor growth. Tumors induced from cells with higher levels of TNFAIP3 had a lower volume compared with ...

"The pharmacological and genetic modulation of astrocytic autophagy pathway can be considered for boosting the detoxifying ...

China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Guangzhou, China ...