The purpose of this study was to find ways to facilitate formulary decisions by an MCO regarding selection of antidepressants ... therapies for patients with major depression.

However, a number of well-controlled clinical trials, meta-analyses and practical clinical studies have found that only a third of such MDD patients remit following adequate antidepressant ...

The use of TCAs has decreased since the discovery of other classes of antidepressants beginning in the 1980's. TCAs are still used to treat major depressive disorder (MDD), though typically only ...

MDD3001 enrolled MDD patients who had not responded well to standard SSRI and SNRI antidepressants and had significant sleep disturbance. Compared to placebo, seltorexant achieved significant ...

The sNDA submission is supported by positive results from two late-stage studies, Studies 501 and 502, that evaluated 42 mg of lumateperone as an adjunctive therapy to antidepressants for MDD.