p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

CDCA7 binds to the hemimethylation site in the major groove of nucleosomal DNA without base-flipping. R274 confers preferential binding of CDCA7 to a hemimethylated CpG. The side chain of Q275 is ...

While it has been known that mutations in the CDCA7 gene cause ICF syndrome, little was known about the gene's molecular function. Now Rockefeller University's Funabiki lab, in close collaboration ...

The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged ...

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role in understanding the complex interplay between genetics and the ...

Triple negative breast cancer (TNBC) remains the most aggressive and deadly type of breast cancer, but new findings from cancer researchers at Brigham and Women's Hospital, a founding member of ...