2008; Daub et al., 2008). Gygi's group looked at phosphorylation changes across the proteome in the mitotic and G 1 phases of the HeLa cell cycle, using stable isotope metabolic labeling to enable ...

The study of the cell cycle focuses on mechanisms that regulate the timing and frequency of DNA duplication and cell division. As a biological concept, the cell cycle is defined as the period ...

BACKGROUND: Many specialized cells in adult organs acquire a state of cell cycle arrest and quiescence through unknown ...

Calcineurin fine tunes the balance between proliferation and differentiation of Notch-responsive progenitors in the pancreatic ducts to enable beta cell regeneration in zebrafish.

When looking at cells with a microscope, the length of different stages of the cell cycle can be estimated using the formula: \(\text{Length of time in phase}=\) \(\frac{\text{observed number of ...

The study addresses the complex regulation of HSCs, highlighting p21's multifunctional nature beyond cell cycle control. Through the use of p21-tdTomato mice, researchers differentiate between p21 ...

Proteins that trigger cell senescence occupy much of the literature on aging, but a small RNA moves into the limelight.

Researchers developed novel genetic tools to trace, ablate, and manipulate p16^Ink4a+^ senescent cells, revealing their ...

A life cycle is the series of stages something passes through during its lifetime. We also use the term for things that are not living, like cell phones. The life cycle for anything you buy includes ...

In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also ...

This new kind of mice, that count with most of the human immune cell types with lower ...