JE: Human genetic studies provide strong target validation for the role of PCSK9 in modulating LDL cholesterol (LDL ... combination with other lipid-lowering agents and as monotherapy.
Current AHA guidelines call for healthy Americans to bring LDL below 100 milligrams per deciliter (mg/dL) of blood, while those who’ve had a heart attack or stroke are encouraged to drop LDL at least ...
Yet in 2009, pediatricians wrote children in the U.S. at least 2.8 million prescriptions for drugs to lower cholesterol; nearly 2.3 million of them were for statins. (not including prescriptions ...
The leading therapeutic classes in 2003 sales were cholesterol-lowering agents, with $13.9 billion in US sales, up 10.9% from 2002; proton pump inhibitors, $12.9 billion, up 12.6%; and SSRI/SNRI ...