Pain is one of the most debilitating symptoms that presents with neuropathy. Neuropathic pain syndrome is a challenge to treat and, even with appropriate evidence-based treatment, only a 40% ...

but NNTs were calculated for many peripheral neuropathic pain conditions. The NNT for tricyclic antidepressants (TCAs) was between 2 and 3, the lowest NNT of all the drug classes studied ...

Tricyclic antidepressants (TCAs ... In addition, TCAs have analgesic effects. They reduce nerve pain by increasing ...

NHS guidelines say: Antidepressants can be used for some chronic-pain conditions, including nerve pain and fibromyalgia Strong opioid painkillers, which can be addictive, are not recommended ...