and severity of hot flashes, although the reductions are not as great as those observed with estrogen therapy. These antidepressants were generally well tolerated, with the primary adverse events ...

The mean reduction in hot flash score in the combined placebo arms of all studies was 24%. The antidepressants paroxetine (10–25 mg per day), fluoxetine (20 mg per day), sertraline (50–100 mg ...

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“As the definitive physiology of hot flashes is not known, I believe it cannot be assumed that the efficacy of the new antidepressants for hot flashes is a class effect,” says lead researcher ...