Primary and review articles published in English were identified by a MEDLINE (1966-June 2003) search using the MeSH terms "hot flashes," "hot flushes," "menopause," and "serotonin reuptake inhibitor.

and severity of hot flashes, although the reductions are not as great as those observed with estrogen therapy. These antidepressants were generally well tolerated, with the primary adverse events ...

The analysis by Loprinzi and co-workers supports the notion that antidepressants and gabapentin decrease menopausal hot flashes. In addition, the study showed that venlafaxine and paroxetine were ...

“As the definitive physiology of hot flashes is not known, I believe it cannot be assumed that the efficacy of the new antidepressants for hot flashes is a class effect,” says lead researcher ...