Primary and review articles published in English were identified by a MEDLINE (1966-June 2003) search using the MeSH terms "hot flashes," "hot flushes," "menopause," and "serotonin reuptake inhibitor.

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“As the definitive physiology of hot flashes is not known, I believe it cannot be assumed that the efficacy of the new antidepressants for hot flashes is a class effect,” says lead researcher ...

The analysis by Loprinzi and co-workers supports the notion that antidepressants and gabapentin decrease menopausal hot flashes. In addition, the study showed that venlafaxine and paroxetine were ...