Published reports on placebo-controlled clinical trials and other studies investigating the use of pure opioid antagonists for the prevention and treatment of opioid-induced pruritus (OIP ...
2 Common symptoms like fatigue and pruritus (chronic itch) are sometimes misdiagnosed as conditions like atopic dermatitis or psoriasis, causing delays in diagnosis and suitable treatment.
In the three aforementioned studies of epidural delivery of naloxone in combination with an opioid (fentanyl or morphine), the frequency of pruritus was decreased, with no reversal of analgesia noted.