Both animals demonstrated significant agitation and pruritus. The rat had moderate pruritus, resulting in alopecia and excoriations on head and neck. The integument of the mouse, however ...
On examination of the colony, severely affected guinea pigs showed intense pruritus, widespread alopecia, and greasy skin with self-inflicted sores. Based on the history and clinical signs ...
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In the three aforementioned studies of epidural delivery of naloxone in combination with an opioid (fentanyl or morphine), the frequency of pruritus was decreased, with no reversal of analgesia noted.
Published reports on placebo-controlled clinical trials and other studies investigating the use of pure opioid antagonists for the prevention and treatment of opioid-induced pruritus (OIP ...
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