The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain. Embodiments of the invention are directed ...

Scientists at the U.S. Department of Veterans Affairs have developed pharmacological compounds to address effects from central and peripheral nervous system injuries, such as spinal cord injuries ...

There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are ...

Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the 2-microglobulin (B2M) level in the mammal in a manner sufficient to ...

A novel gene (EPM2A) that is deleted or mutated in people with Lafora's disease is described. The EPM2A gene encodes a protein having an active catalytic site of a protein tyrosine phosphatase. Many ...

The present invention is directed to a method for preparing 5-nitrotetrazolate using a strongly acidic ionic cation exchange resin that has improve yields over prior art methods. The methods disclosed ...

Research scientists from the Smithsonian Museum Conservation Institute and the U.S. Naval Research Laboratory have invented a novel in-line trace gas permeator. The low-footprint, refillable trace gas ...

A mouth supported tongue/hard palate pressure sensor allows pressures to be measured between the tongue and hard palate in an environment that closely approximates the configuration of the tongue and ...

The present invention includes a method of utilizing four peptide hormones to inhibit the growth of cancer(s). A dramatic decrease in the number of human pancreatic adenocarcinoma cells (i.e., the ...

Scientists at the U.S. Department of Veterans Affairs (VA) have recently identified the use of a generic drug, Cilostazol, for the new indication of coronary artery disease. PDE3A and PDE3B are two ...

The present invention includes compositions that are useful in treating, ameliorating, or preventing nerve agent poisoning. The present invention also includes methods of preventing, treating or ...