A research team has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in triggering autophagy.

Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and ...

Autophagy is a natural process by which a cell breaks down old, damaged, unnecessary, or dysfunctional components within a cell and then repurposes those components for fuel and to build or maintain ...

Aging diminishes autophagy in short-lived model organisms. This study uncouples macroautophagy and mitophagy in the aging mouse brain at the single-cell level in vivo by profiling two optical reporter ...

Endurance exercise also enhances the ADP/ATP ratio, thereby promoting mitochondrial OXPHOS and reducing mitochondrial oxidative stress. The release of exerkines such as musclin, FGF21, FSTL1, and ...

Molecular Biology Institute University of California Los Angeles CA USA Department of Pathology and Laboratory Medicine University of California Los Angeles CA USA Department of Bioengineering ...

Autophagy is a complex cellular process involving the seclusion of cytoplasmic material ... This results in elongated mitochondria, increased oxidative phosphorylation (OXPHOS), and elevated ATP ...

Overcome the Challenge of Treating Unmet Medical Needs Caused by Mitochondrial Dysfunction The 2nd annual Mitochondria-Targeted Drug Development Summit returns as the only industry-led meeting ...

Airway macrophages (AM) are the predominant immune cell in the lung and play a crucial role in preventing infection, making them a target for host directed therapy. Macrophage effector functions are ...