A mouse xenograft model of DLBCL tumors was used to characterize the role of TNFAIP3 expression tumor growth. Tumors induced from cells with higher levels of TNFAIP3 had a lower volume compared with ...

New research shows astrocytes can remove Alzheimer’s-related amyloid-beta via autophagy, offering a promising new direction ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel ...

As a highly conserved cellular process, autophagy plays a critical role during both cardiac development and pathogenesis. During cardiovascular pathogenesis, autophagy mechanisms are reactivated ...

On one hand, autophagy helps mitigate oxidative stress by removing damaged mitochondria, which are significant sources of ROS. On the other hand, chronic oxidative stress can impair autophagic ...

Autophagy is a natural process by which a cell breaks down old, damaged, unnecessary, or dysfunctional components within a cell and then repurposes those components for fuel and to build or maintain ...

Here, we show that RNF144B specifically interacts with MDA5 and promotes K27/K33-linked polyubiquitination of MDA5 at lysine 23 and lysine 43, which promotes autophagic degradation of MDA5 by p62.

Overexpression of the non-canonical Notch ligand DLK1 stimulates non-autophagic Golgi-LC3 lipidation. Post-Golgi trafficking inhibition is the primary cause of Golgi-LC3 lipidation. The WD40 domain of ...

Monitoring autophagic flux is necessary for most autophagy studies. The autophagic flux assays currently available for mammalian cells are generally complicated and do not yield highly quantitative ...

Neurons face unique challenges of transporting nascent autophagic vacuoles (AVs) from distal axons toward the soma, where mature lysosomes are mainly located. Autophagy defects have been linked to ...