The mean reduction in hot flash score in the combined placebo arms of all studies was 24%. The antidepressants paroxetine (10–25 mg per day), fluoxetine (20 mg per day), sertraline (50–100 mg ...

Primary and review articles published in English were identified by a MEDLINE (1966-June 2003) search using the MeSH terms "hot flashes," "hot flushes," "menopause," and "serotonin reuptake inhibitor.

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“As the definitive physiology of hot flashes is not known, I believe it cannot be assumed that the efficacy of the new antidepressants for hot flashes is a class effect,” says lead researcher ...