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Mitochondrial dysfunction is a key factor in the development of atherogenesis. METTL4 (methyltransferase-like protein 4) mediates N6- methyldeoxyadenosine (6mA) of mammalian mitochondrial DNA (mtDNA).

Our vision is to innovate and incorporate promising technologies to communicate freely available, high-priority, high-quality content, which accelerates scientific progress and advances heart and ...

As the most upstream component of the renin-angiotensin-aldosterone system, angiotensinogen represents an attractive target ...

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BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a major health concern. Pathological stimuli and interactions between cardiac fibroblasts (CFs) and other cell types may lead to ...

Almost everyone who first sees moving heart walls, valves, and flows by echocardiography experiences fascination and wonder. Echocardiography is unique among cardiac imaging modalities because It ...

Myocardial infarction (MI) is a complex disease caused by both lifestyle and genetic factors. This study aims to investigate the predictive value of genetic risk, in addition to traditional ...

Heart failure with preserved ejection fraction (HFpEF) is a major public health problem characterized by multiple simultaneous comorbidities whose specific contribution is challenging to disentangle ...

Department of Neurosurgery and Neurology (Y.X., B.S., C.L., C.W., J.D., R.M., F.Y., J.C., X.J.), Xuanwu Hospital, Capital Medical University. China-America Institute ...

Declining cardiovascular mortality rates have been well-documented, yet temporal trends of sudden cardiac death (SCD) in young individuals remain unclear. We provide contemporary nationwide estimates ...