Chronotropic Incompetence: Causes, Consequences, and Management
2011年3月3日 · Chronotropic incompetence (CI), broadly defined as the inability of the heart to increase its rate commensurate with increased activity or demand, is common in patients with cardiovascular disease, produces exercise intolerance which impairs quality-of-life, and is an independent predictor of major adverse cardiovascular events and overall ...
Chronotropic - Wikipedia
Chronotropic effects (from chrono-, meaning time, and tropos, "a turn") are those that change the heart rate. Chronotropic drugs may change the heart rate and rhythm by affecting the electrical conduction system of the heart and the nerves that influence it, such as by changing the rhythm produced by the sinoatrial node. Positive chronotropes ...
Are We Approaching Chronotropy (In)competently?∗ - JACC: Heart …
An appropriate chronotropic response is essential for increasing cardiac output (CO) in order to meet the body’s metabolic needs during exertion. The relationship between heart rate (HR) and CO is mediated by stroke volume (SV) and summarized by the well-known equation: CO = …
Chronotropic Incompetence | Circulation - AHA/ASA Journals
2011年3月8日 · Chronotropic incompetence is common, an important cause of exercise intolerance, and an independent predictor of major adverse cardiovascular events and mortality. It is present in up to one third of patients with HF and contributes to their prominent exertional symptoms and reduced quality of life.
Pacemaker Channels and the Chronotropic Response in Health …
2024年5月9日 · This mechanism is termed chronotropic effect and enables smooth changes in HR, without rapid fluctuations or rhythm disturbances. Three components are associated with the chronotropic response, which are (1) the actual HR, (2) the variability of HR at a given time, and (3) the initiation site of pacemaker activity . When the activity state ...
Chronotropy: The Cinderella of Heart Failure Pathophysiology and ...
The impaired chronotropic response in HF patients has important implications for function, quality-of-life, and prognosis. It also has therapeutic implications since reversing such a deficit would represent a rather large, clinically meaningful effect size.
Mechanisms of Chronotropic Incompetence in Heart Failure …
2020年3月13日 · Chronotropic incompetence is common in heart failure with preserved ejection fraction (HFpEF) and is associated with impaired aerobic capacity. We investigated the integrity of cardiac β–receptor responsiveness, an important mechanism involved in exertional increases in HR, in HFpEF and control subjects. Methods:
Chronotropic Intolerance: An Overlooked Determinant of …
2019年3月22日 · Chronotropic intolerance (CI) is defined by a range of different criteria, including; failure to achieve age-predicted maximal heart rate, delays in achieving age-predicted maximal heart rate, inadequate heart rates at submaximal workloads, slowed post-exertion recovery heart rate, or heart rate fluctuations (21, 22). The prevalence of CI is ...
19.4 Cardiac Physiology – Anatomy & Physiology
Identify cardiovascular centers and cardiac reflexes that regulate heart function. Describe factors affecting heart rate and force of contraction. Explain the connection between preload, contractility, afterload and stroke volume. Distinguish between positive and negative inotropic factors.
Difference between Inotropic, Chronotropic and Dromotropic
Key Difference: Inotropic, Chronotropic, and Dromotropic are different types of cardiac drugs. This classification is based on the way these drugs are used for the treatment of a particular condition. Inotropic drugs affect the force of cardiac contraction. Chronotropic drugs affect the heart rate.
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