microRNA - Wikipedia
网页microRNA. Not to be confused with mitochondrial DNA (m (t)DNA); or messenger RNA (mRNA). Pre-miRNA instead of Pri-miRNA in the first point of mechanism. Diagram of microRNA (miRNA) action with mRNA. microRNA (miRNA, µRNA) are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. [ 1 ]
microRNAs in action: biogenesis, function and regulation
网页2023年6月28日 · Here, we summarize the current understanding of miRNA biogenesis, function and regulation, and outline challenges to address in the future.
An overview of microRNAs: Biology, functions, therapeutics, and ...
网页MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis.
What to Know About MicroRNA, the Nobel-Prizewinning Discovery
网页2024年10月7日 · Two scientists have been award the 2024 Nobel Prize in Physiology or Medicine for their discovery of microRNA. Victor Ambros, professor of molecular medicine at the University of Massachusetts ...
Overview of MicroRNA Biogenesis, Mechanisms of Actions, …
网页2018年8月3日 · In this review, we provide an update on canonical and non-canonical miRNA biogenesis pathways and various mechanisms underlying miRNA-mediated gene regulations. We also summarize the current knowledge of the dynamics of miRNA action and of the secretion, transfer, and uptake of extracellular miRNAs.
MicroRNAs and their targets: recognition, regulation and an
网页2012年3月13日 · MicroRNAs (miRNAs) function as 21–24-nucleotide-long guides that regulate the expression of mRNAs containing complementary sequences. Although plant miRNAs typically base-pair perfectly to ...
Nobel Prize in medicine 2024 awarded for work on the discovery …
网页2024年10月7日 · The 2024 Nobel Prize in physiology or medicine has been awarded to US scientists Victor Ambros and Gary Ruvkun for their work on the discovery of microRNA, a molecule that governs how cells in the ...
MicroRNA: trends in clinical trials of cancer diagnosis and therapy ...
网页2023年7月10日 · As a type of short noncoding RNAs, microRNA (miRNA) undoubtedly plays a crucial role in cancer development.
‘Out of the blue’ discovery of RNAs that regulate genes ... - Science
网页2024年10月7日 · In addition to this and last year’s prizes, researchers who discovered RNA interference, a process by which strands of RNA silence particular genes, won in 2006, and research on RNA’s role as enzymes was recognized in 1989. The discovery of mRNA itself received the Nobel Prize in Physiology or Medicine in 1965. doi: 10.1126/science.zyal6m9.
MicroRNA - an overview | ScienceDirect Topics
网页Each microRNA gene produces a primary microRNA transcript, which is capped at the 5′-end, polyadenylated at the 3′-end, and can be spliced similarly to the regular mRNA (not shown), and folded into so-called pri-miRNA––a double-stranded, hairpin-loop structure, several hundred base pairs in length. microProcessor protein complex cleaves ...
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