Paneth cell - Wikipedia
Paneth cells are cells in the small intestine epithelium, alongside goblet cells, enterocytes, and enteroendocrine cells. [1] Some can also be found in the cecum and appendix.
潘氏细胞 - 百度百科
潘氏细胞（或称帕内特细胞，Paneth cell）是小肠内一种少见的细胞，提供宿主防卫微生物的侵犯。 其功能的类似于中性粒细胞。 在细菌或细菌抗原侵犯机体时，潘氏细胞分泌一些抗菌分子如防御素[1][2]到小肠管腔的绒毛，以助于维持胃肠道屏障。
Paneth cells, antimicrobial peptides and maintenance of intestinal ...
2011年3月22日 · In this Review, we provide an overview of the intestinal microbiota and describe the cell biology of Paneth cells, emphasizing the composition of their secretions and the roles of these...
Paneth cells as the cornerstones of intestinal and organismal …
2022年12月27日 · Paneth cells are the main producers of AMPs in the gastrointestinal tract, making them key players in sensing and controlling the microbiome composition. Thereby, they can preserve homeostasis and prevent bacteria from crossing the intestinal barrier.
The Paneth Cell: The Curator and Defender of the Immature Small ...
2020年4月3日 · Paneth cells are highly specialized secretory epithelial cells located in the small intestinal crypts of Lieberkühn. The dense granules produced by Paneth cells contain an abundance of antimicrobial peptides and immunomodulating proteins that function to regulate the composition of the intestinal flora.
Frontiers | The Paneth Cell: The Curator and Defender of the …
2020年4月2日 · This review will provide an up to date and comprehensive look at Paneth cell ontogeny, the impact Paneth cells have on the host-microbial axis in the immature intestine, and the repercussions of Paneth cell dysfunction or loss on injury and repair mechanisms in …
Paneth cells in intestinal physiology and pathophysiology
2017年11月11日 · The review provides an overview of the key points of Paneth cell activities in intestinal physiology and pathophysiology. Keywords: Antimicrobial peptide, Paneth cell, Crohn’s disease, Microbiome, Small intestine. Core tip: Paneth cells physiologically locate in small intestinal crypts.
潘氏细胞 - 维基百科，自由的百科全书
2022年10月26日 · 潘氏细胞 （或称帕内特细胞、Paneth cells、PCs）是起源于肠隐窝干细胞的 小肠 腺特征性细胞，与隐窝干细胞间隔排列于小肠腺的底部，并且遍布于整个小肠。. 胞体呈锥体形，胞质顶部的粗大嗜酸性颗粒的主要成分为防御素 (80% [1])、 溶菌酶 、SPLA2、血管生成因子 ...
潘氏细胞 - 维基百科，自由的百科全书
潘氏細胞 （或稱帕內特細胞、Paneth cells、PCs）是起源於腸隱窩乾細胞的 小腸 腺特徵性細胞，與隱窩乾細胞間隔排列於小腸腺的底部，並且遍布於整個小腸。. 胞體呈錐體形，胞質頂部的粗大嗜酸性顆粒的主要成分為防禦素 (80% [1])、 溶菌酶 、SPLA2、血管生成因子 ...
Control of Paneth Cell Fate, Intestinal Inflammation, and ... - Cell …
2016年9月20日 · Paneth cells are a highly specialized population of intestinal epithelial cells located in the crypt adjacent to Lgr5 + stem cells, from which they differentiate through a process that requires downregulation of the Notch pathway. Their ability to store and release antimicrobial peptides protects the host from intestinal pathogens and controls ...